Monday, 2 May 2011

How Does ICSI Work?

My colleagues, Drs. Van Steirteghem and Devroey from the Free University in Brussels, and I showed how we can take a single, almost non-moving “dead” appearing sperm and inject it into a woman’s egg, getting a normal embryo and a completely normal baby. So far, over 100,000 babies have been born with this new technique, from men who were otherwise considered hopelessly sterile. The babies are physically, mentally, and genetically normal, no matter how poor or miserable the sperm of the father.

We can take a man who would otherwise have to resort to donor sperm, and if we can find just a few weak sperm in his otherwise sterile appearing ejaculate, it is more than enough to microsurgically inject these few sperm into his wife’s eggs, fertilize them normally, and get her pregnant.

If there is absolutely no sperm in the ejaculate, we can perform a testicle biopsy, remove the few non-moving sperm that we find through a highly refined ultra micropipette, inject it into the wife’s egg and still get her pregnant. Even in testicles where allegedly there is no sperm production, we can usually (but not always) find a few sperm, which is enough for successful ICSI. Even in cases where we find no sperm, we can safely freeze the wife's eggs and save them for a future date when further breakthroughs will allow us to find sperm.

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