The History of IVF -The Milestones

2004

Successful pregnancy and delivery following combined treatment of In Vitro Maturation (IVM) and Testicular Sperm Extraction (TESE). (Fuchinoue K, Nakajo Y, Yagi A, Takeda M, Kyono K. Successful pregnancy and delivery following combined treatment of in vitro maturation (IVM) and testicular sperm extraction (TESE): a case report. J Assist Reprod Genet.

Jaques Donnez reporting on the first Live birth after orthotopic transplantation of cryopreserved ovarian tissue (Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, Martinez-Madrid B, van Langendonckt A. vebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet.

Gardner and colleagues performed the world’s first prospective single blastocyst trial, which showed the feasibility of SBT and in keeping high pregnancy rates (Gardner DK, Surrey E, Minjarez D, Leitz A, Stevens J, Schoolcraft WB. Single blastocyst transfer: a prospective randomized trial. Fertil Steril.

The first preimplantation HLA matching for stem-cell transplantation to an affected sibling (Verlinsky Y, Rechitsky S, Sharapova T, Morris R, Taranissi M, Kuliev A. Preimplantation HLA testing. JAMA.

First report of fertility preservation for cancer patients using IVM and oocyte vitrifica­tion (Rao GD, Chian RC, Son WS, Gilbert L, Tan SL. Fertility preservation in women undergoing cancer treatment.

First report on oocyte cryopreservation to save fertility in cancer patients.
Porcu E, Fabbri R, Damiano G, Fratto R, Giunchi S, Venturoli S. Oocyte cryopreservation in oncological patients.  Eur J Obstet Gynecol Reprod Biol. 

The first reported live born following preimplantation genetic diagnosis for Retinoblastoma (Xu K, Rosenwaks Z, Beaverson K, Cholst I, Veeck L, Abramson DH. Preimplantation genetic diagnosis for retinoblastoma: the first reported liveborn.

First report on a natural cycle in IVF combined with IVM as a potential approach to infertility treatment (Chian RC, Buckett WM, Abdul Jalil AK, Son WY, Sylvestre C, Rao D, Tan SL. Natural-cycle in vitro fertilization combined with in vitro maturation of immature oocytes is a potential approach in infertility treatment. Fertil Steril.