1999
First unaffected pregnancy using preimplantation genetic diagnosis for sickle cell anemia. (Xu K, Shi ZM, Veeck LL, Hughes MR, Rosenwaks Z. First unaffected pregnancy using preimplantation genetic diagnosis for sickle cell anemia. JAMA. 1999, 12;281(18):1701-6).
Birth following vitrification of human oocyte (Lilia Kuleshova, Luca Gianaroli, Cristina Magli, Anna Ferraretti, and Alan Trounson. Birth following vitrification of a small number of human oocytes: Case Report. Hum. Reprod. 1999 14: 3077-3079).
Chian et al. demonstrated that hCG priming prior to immature oocyte retrieval in women with PCO increases the maturation rate and produces high pregnancy rates of 40% per IVM started cycle (Chian, R.C., Gülekli, B., Buckett, W.M. and Tan, S.L. Priming with human chorionic gonadotrophin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome. N. Eng. J. Med., 1999;341, 1624–1626).
World’s first IVF/ICSI pregnancy and live-birth after successful air transport of oocytes reported by the McGill Reproductive Centre, enabling the creation of an air-transport IVF program in large countries with scattered populations or in areas remote from infertility centers (Buckett WM, Fisch P, Dean NL, Biljan MM, Tan SL. In vitro fertilization and intracytoplasmic sperm injection pregnancies after successful transport of oocytes by airplane. Fertil Steril. 1999;71(4):753-5).
Cryopreserved oocytes and testicular sperm: first ever birth. (Porcu E, Fabbri R, Petracchi S, Ciotti PM, Flamigni C. Ongoing pregnancy after intracytoplasmic injection of testicular spermatozoa into cryopreserved human oocytes. Am J Obstet Gynecol. 1999;180:1044-5).
Cryopreserved oocytes and epididimal sperm: first ever birth. (Porcu E, Fabbri R, Ciotti PM, Petracchi S, Seracchioli R, Flamigni C. Ongoing pregnancy after intracytoplasmic sperm injection of epididymal spermatozoa into cryopreserved human oocytes. J Assist Reprod Genet. 1999;16(5):283-5).
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