The History of IVF -The Milestones

1997

First report on cytoplasmic transfer (Cohen J, Scott R, Schimmel T, Levron J, Willadsen S. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet, 1997, 19;350(9072):186-7)

Sun, Jurisicova and Casper described the use of TUNEL for detection of DNA fragmentation in sperm and correlation with IVF outcome. They showed almost uniform presence of DNA fragmentation in round spermatids as the explanation for failure to achieve pregnancy with these immature gametes. (Sun JG, Jurisicova A, Caspe RF. Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol Reprod. 1997 Mar;56(3):602-7).

First births of babies from frozen oocytes following use of ICSI: - Porcu et al, Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. (Porcu E, Fabbri R, Seracchioli R, Ciotti PM, Magrini O, Flamigni C. Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. Fertil Steril. 1997;68(4):724-6).

First report on cytoplasmic transfer (Cohen J, Scott R, Schimmel T, Levron J, Willadsen S. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet, 1997;19;350:186-7).

Falloposcopic GIFT: Births after transcervical gamete intrafallopian transfer with a falloposcopic delivery system. (Porcu E, Dal Prato L, Seracchioli R, Petracchi S, Fabbri R, Flamigni C. Births after transcervical gamete intrafallopian transfer with a falloposcopic delivery system. Fertil Steril. 1997 Jun;67(6):1175-7).

Pregnancy after treatment with three recombinant gonadotropins (Agrawal R, West C, Conway GS, Page ML, Jacobs HS. Pregnancy after treatment with three recombinant gonadotropins. Lancet. 1997;4;349:29-30).